Is The Dr. Oligo 768XLc The Right Oligo Synthesizer For You?

Are you in search of a synthesizer that aligns perfectly with your laboratory’s needs? Biolytic’s Dr. Oligo 768XLc synthesizer is designed to enhance oligo synthesis quality, performance, and speed with cycle times as short as 6 minutes and 40 seconds for a single 384-well plate and 9 minutes and 45 seconds for two plates. This model includes a patent-pending nozzle system that dispenses 16 or more nozzles with accuracy down to 2 microliters. It can handle up to 25 total reagents and 15 special reagents. The system aims to achieve high chemical reaction efficiency with minimal reagent use, addressing challenges such as chemistry overconsumption and inconsistencies in well-to-well flow rates.

At Biolytic, we collaborate with our customers to find the most suitable synthesizer for their requirements. The Dr. Oligo 768XLc is a versatile instrument widely used in biotech labs, pharmaceutical facilities, educational institutions, and various industries worldwide. We proudly support a diverse clientele in over 50 countries, providing cutting-edge technology and exceptional service to advance their research. We recommend the Dr. Oligo 768XLc if you need to synthesize hundreds of oligos per day or week between scales from 2 nmol to 100 nmol.

Meet The Dr. Oligo 768XLc

Biolytic Lab Performance, Inc. has 30 years of experience in developing reliable and efficient oligo synthesizers that customers from all over the world use to produce various oligonucleotides. From applications like gene synthesis, genetic diagnostic test kits, PCR/RT-PCR, siRNA/RNAi, miRNA, CRISPR Cas9, and DNA/RNA sequencing, to broader areas such as evolutionary history, forensics, immunotherapy, diagnostic and therapeutic research, our synthesizers meet diverse scientific needs. They are also instrumental in high-throughput screening, modified oligos, mixed backbones, LNAs, and the visual detection of virus RNA, including COVID-19, following RT-LAMP amplification with DNA primers. The Dr. Oligo line has evolved in tandem with cutting-edge discoveries, and the Dr. Oligo 768XLc will continue to play a significant role in advancing modern science.

30+ years in the industry, in over 50+ countries. We proudly support biotech labs, pharmaceutical facilities, educational institutions, and more worldwide.
Dr. Oligo 768XLc

Feature Highlights:

  • Throughput: Ultra-High Throughput
  • Synthesize: Capable of synthesizing DNA, RNA, LNA, 2′-Modified RNA, Mixed Backbones of DNA and RNA, and more
  • Oligos Per Run: Can produce between 1 to 768 oligonucleotides in a single run
  • Synthesis Scale: Offers synthesis scales ranging from 2 nmol to 100 nmol
  • Dimensions: The compact design measures 62.68in x 19in x 31.67in
  • Max Reagents: Supports up to 25 reagents, with 15 special reagents for versatile synthesis options
  • Qualification Services: Includes Installation Qualification (IQ), Operational Qualification (OQ), and Preventive Maintenance (PM) services to ensure optimal performance
  • Modern Software: Equipped with advanced software features such as Hardware Mapping, Protocol Editor, Ox and Cap Configuration, Full Manual Mode, Security & Encryption, Software Updates, and more

Biolytic Consumables

In addition, our quality-tested 384-Well Plates are fully compatible with the Dr. Oligo 768XLc, offering flexible scale options from 2 nmol to 100 nmol. This ensures you can efficiently meet your oligonucleotide synthesis needs with precision and reliability.

Quality Test

All synthesis consumables pass through a rigorous quality control process to ensure efficient and consistent oligo production. They are lot tracked and shipped with certificates verifying that they have been tested and meet or exceed all factory-documented specifications, ensuring they are ready for synthesis.

Ready to use Protocol

Biolytic consumables are engineered for immediate use, minimizing downtime and maximizing synthesis efficiency. The Dr. Oligo 768XLc features built-in protocols that seamlessly integrate with our consumables, capable of synthesizing DNA, RNA, LNA, 2′-Modified RNA, Mixed Backbones of DNA and RNA, and various other molecules. These protocols are customizable to accommodate your specific synthesis needs, ensuring flexibility and precision in every synthesis run.

Our quality tested 384-Well Plates are compatible with our Dr. Oligo 768XLc, offering scale options from 2 nmol to 100 nmol.

Dr. Oligo 768XLc Operational Tips:

At Biolytic Lab Performance, Inc, we are dedicated to providing comprehensive support to ensure that your instruments remain up-to-date and operational at all times. These tips will help keep maintenance costs low and ensure that your synthesis processes run as efficiently as possible, maximizing productivity and minimizing disruptions.

🔹 Flush reagents with ACN if instrument unused for more than three days, keep switch in wash position.
🔹 Frequent use of the XLc leads to consistently good synthesis yields.
🔹 Use high quality consumables and ready to use protocols
🔹 Do not leave reagents in valves or reagent lines to reduce potential damage.
🔹 After every synthesis, it is recommended to flush the dispense lines with ACN and gas. On the Dr. Oligo 768XLc, this can be done manually or automatically.

Software and Protocol

The Dr. Oligo 768XLc’s software and protocols feature a user-friendly interface that guides you through each step of the synthesis process, ensuring smooth operation even for those new to oligonucleotide synthesis. The Dr. Oligo 768XLc comes pre-loaded with ready-to-use protocols, eliminating the need for manual input. Simplify your oligo synthesis steps!

Customer FAQs

As professionals in the field of DNA/RNA synthesis, we are dedicated to providing end-to-end solutions to ensure your synthesis processes run smoothly. To support you in achieving optimal results with the Dr. Oligo 768XLc, we’ve compiled answers to some of our customers most frequently asked questions.

1. Which consumables does the Dr. Oligo 768XLc support?

The Dr. Oligo 768XLc supports: 384-Well Plates, End Line Filters, Molecular Traps, and Bottles

2. How many oligos can it make in a day?

The total run time to synthesize 768 oligos is as quick as 2 hours and 13 minutes for one 384-well plate, and 3 hours and 15 minutes for two 384-well plates (9 minutes per cycle at 20 mers / 25 nm scale)

3. What volume of reagent does the Dr. Oligo 768XLc consume in a run?

The amount of reagents consumed by the instrument varies greatly depending on the number of oligos being synthesized, the scale of those oligos, and the length of those oligos. Based on these factors, our Biolytic Reagent Calculator can be used to estimate the amount of reagent used, and the cost of synthesis based on that reagent used.

Biolytic Reagent Calculator:

4. What volume is needed to fill the reagent lines?

245mL top reagents, 600uL low volume

5. Do you need a bottle in every position, even empty?

Yes, bottles are required to keep pressure consistent.

Need assistance or have any additional questions? Our dedicated teams are here to address any synthesis-related questions or concerns you encounter. We collaborate closely with you to guarantee that you have the support and resources necessary for successful oligo synthesis.