6 Reasons Why Companies Are Making Their Own Oligos [2023]

Why purchase a DNA RNA oligonucleotide synthesizer?

Thinking about taking oligo synthesis in-house? There are several reasons why purchasing a DNA RNA oligonucleotide synthesizer instead of solely relying on ordering oligos from vendors can be advantageous. Here are a few key points:

(Prefer to watch a video? Scroll down to the bottom of the page)

1. Cost-effectiveness

Investing in a DNA RNA synthesizer can be cost-effective in the long run, especially if your laboratory or research facility has a consistent demand for oligonucleotides. Instead of paying for each individual oligo order, synthesizing oligos in-house can significantly reduce costs per base, particularly for high-throughput projects.

2. Time efficiency

Having a DNA RNA synthesizer on-site allows you to synthesize oligos immediately, without relying on external vendors’ production and delivery timelines. This can save valuable time, especially when working on time-sensitive experiments or projects that require rapid oligo synthesis and turnaround.

3. Flexibility and customization

With an in-house DNA RNA synthesizer, you have greater control over the synthesis process. You can easily modify and customize oligos by incorporating specific modifications, labels, or conjugates to meet the specific requirements of your research. This level of flexibility may not be readily available when ordering from external vendors.

4. Enhanced confidentiality and data security

In some research areas, such as sensitive or confidential projects, it may be crucial to maintain control over the synthesis process and protect intellectual property. Having an in-house synthesizer ensures confidentiality and mitigates potential risks associated with sharing proprietary information with external vendors.

5. Iterative experimentation and total control over QC processes

By having immediate access to a DNA synthesizer, you can quickly synthesize and test different oligo designs, optimize sequences, and iterate experiments more efficiently. This empowers researchers to troubleshoot and refine protocols in real-time, accelerating the progress of their work while having full control over the QC process.

6. Long-term availability

External oligo vendors may occasionally discontinue or change their product offerings, affecting the availability of specific sequences or modifications. By having a DNA synthesizer, you have greater control over the availability of custom oligos, ensuring you can continue your experiments without interruption.

It’s important to note that the decision to purchase a DNA RNA synthesizer should be based on factors such as the volume and frequency of oligo synthesis, the specific needs of your research projects, and the available resources and expertise within your laboratory or organization. Assessing these factors will help you determine whether in-house synthesis is a viable and beneficial option for your research needs.

Biolytic Lab Performance, Inc. offers everything you need to get started synthesizing your own DNA RNA oligos. We have high quality synthesis consumables, oligo synthesizers are varying throughputs, and post-synthesis accessories for processing your oligos. Check out our end-to-end offerings here: Oligo / RNA / DNA Synthesizers (biolytic.com).

Leave a Reply

Your email address will not be published. Required fields are marked *