We’re excited to introduce the latest software update for our Dr. Oligo XLc series of DNA RNA oligonucleotide synthesizers, packed with enhancements, expanded capabilities, and crucial fixes to optimize your oligonucleotide synthesis process.
What’s New?

✅ Bug Fixes & Performance Enhancements
- Enhancements improved overall stability and reliability in daily use
✅ Expanded System Capabilities
- Enhanced support for additional hardware components for more flexible configurations.
- Broader compatibility with a range of oxidizers, giving you more options.
- Significantly increased reagent capacity to 49 on select systems, allowing for greater throughput and efficiency.
✅ Improved Reagent & Synthesis Tracking
- New user-defined reagent volume tracking and notifications help you stay ahead of supply needs.
- More robust synthesis logging ensures better data integrity and easier traceability.
- Updated valve logging offers clearer, more consistent reporting.

✅ User Interface & Usability Updates
- Streamlined main UI with a cleaner layout for less clutter and faster navigation.
- Revised synthesis setup workflow that removes unnecessary steps and ensures proper protocol validation.
- Enhancements in the synthesis run interface now include real-time reagent tracking details.
✅ Settings & Compatibility Improvements
- Improved settings file compatibility checks automatically prevent errors from incompatible configurations.
- More control over hardware settings, including a dedicated directory for saving and retrieving files.
✅ Advanced Flushing & Delivery Controls
- Flushing and Delivery Mode tab now offers:
- Expanded flushing options (time-based, always-on, or only when used) give you more control over reagent management.
- A new “Flush Volume” feature lets you easily set default volumes for synthesis and Auto-Prime.
- Expanded reagent flushing to all reagents.
- New “Flush Volume” column to set default flushing volume for synthesis and Auto-Prime.
- Flow Correction improvements include quicker volume estimates for selected reagents.

✅ Simplified Licensing & Support
- Revised Product ID process reduces the need for manual license support.
- An updated support page enables direct license updates for seamless maintenance.
These improvements provide greater flexibility, more powerful tracking tools, and a more intuitive user experience—ultimately helping you streamline your synthesis workflows and focus on consistent, high-quality results.

The Dr. Oligo XLc Line of Oligonucleotide Synthesizers
The Dr. Oligo XLc series is designed to deliver high-throughput, high-quality oligonucleotide synthesis with precision, efficiency, and scalability. Engineered for both research and industrial-scale production, these synthesizers offer flexible configurations, accommodating a wide range of synthesis scales and reagent options.
With automated workflows, advanced reagent tracking, and customizable synthesis protocols, the Dr. Oligo XLc line provides unmatched reliability for labs requiring consistent, reproducible results. Our commitment to continuous software updates ensures that your instrument stays cutting-edge, adaptable, and optimized for evolving synthesis demands—future-proofing your investment for years to come.
The latest Dr. Oligo XLc Software Version 6.2 is now available! Customers with an active warranty or an active Gold Service Plan are eligible for this update. Additionally, all new Dr. Oligo 192XLc and Dr. Oligo 768XLc systems will ship with the new 6.2 software pre-installed. To upgrade or for any questions, please contact us—our team is ready to assist you!